Sarah Wayne Callies is opening up about the "rampant misogyny" she faced while filming Prison Break – including a time she allegedly was spat on by a male colleague.

The US actress made the revelation during her appearance on the Broad Ideas podcast Monday, after explaining to listeners that she's recently been re-watching the popular TV series.

Callies said that revisiting the TV show, which aired from 2005 to 2009, has allowed her to appreciate her time on set despite "all of the challenges" she initially dealt with while being "the only woman around."

She claimed there were "definitely two edges to that sword," as she recalled, "I've had an actor on that show spit in my face.

Callies, 46, promised fans that she will elaborate further on the incident in a future episode of her Prison Breaking podcast with former co-star Paul Adelstein.

"We will talk about it some day, but … there were things. Like, I would go home some nights and have to spend an hour talking my husband out of going to hospitalise somebody," she added.

The Walking Dead star furthered, "Some of the guys were great, and some of them were totally gentlemen."

While Callies didn't mention any names, the hit show starred Dominic Purcell and Wentworth Miller and was the start of new fame for many of the actors, which often led to chaos.

Initially, the mother-of-one didn't want to re-watch the show because she feared it would send her "into a spiral" of "'What did I let them do to me? What did I let them say to me? What did I put up with? What did I not report?'"