"Two and a Half Men," a CBS blockbuster, captivated 13 to 16 million viewers per season, turning its cast into stars. The show, centered around Charlie Sheen's character, Charlie Harper, featured his brother and nephew moving in after a divorce. It became famous for its array of guest stars, often as Charlie's love interests.

Melanie Lynskey, who played stalker Rose, transitioned to acclaimed roles in "Yellowjackets" and "The Last Of Us," winning a Critics' Choice Award. April Bowlby, as Kandi, evolved into Rita Farr in "Titans" and "Doom Patrol." Brooke Shields, known as Danielle, voiced in "Mr.

Charlie Sheen's ex, Denise Richards, appeared as Lisa, later joining "The Real Housewives of Beverly Hills." Jennifer Taylor, Charlie's love Chelsea, guest-starred in "Shameless" and "NCIS." Jenny McCarthy, who played Courtney Leopold, became a judge on "The Masked Singer."

Each star's journey post-"Two and a Half Men" reflects their diverse talents and enduring appeal.