The good-looking pair tied the knot in an 'intimate' ceremony attended only by 'close family and friends,' a representative for the 36-year-old actress told People.
The Tony-winning actress got engaged to Debolt, a Los Angeles-based business analyst, during a vacation in Paris last summer. They were married in New York.
Dependence Day: Sara Ramirez said 'I do' to long time fiance Ryan Debolt on July 4th in New York
Back in September, the voluptuous star spoke to Latina.com about starting a family.
'I'm definitely thinking about it - I will say that,' said Sara, who won a Tony for her part in the Broadway musical, Spamalot.
'I'm very aware of how old I am and I'm very aware of what that means in terms of statistics, and so, yes, I'm considering it,' Sara revealed.
'The clock's ticking, and I totally hear it!'
It's complicated: Sara plays an orthopedic surgeon on Grey's Anatomy who is in a lesbian relationship with another doctor
Art imitates life: Sara plays Dr. Torres, who marries fellow doctor, Arizona
Sara, who was born in Mexico, joined the cast of Grey's Anatomy in its second season. Her character Callie Torres, a beautiful Latina heavy-set doctor, wasn't meant to last.
But the fan response over her portrayal of the doctor convinced Grey's producers to bring her back.
She is now one of the key cast members and plays the lesbian partner of pediatrician Arizona, played by actress Jessica Capshaw.
On the season 8 finale of Grey's, Ramirez' character was left dangling as Arizona suffered a terrible plane crash and was trapped in the wilderness.