Exercise in hot conditions can be risky due to increased core temperature and heart rate, leading to dehydration and heat-related illnesses. The American College of Sports Medicine suggests considering the heat index, which combines temperature and humidity, to evaluate safety. If the heat index is 90°F (32°C) or higher, caution should be exercised. Staying well-hydrated, wearing appropriate clothing, and modifying exercise plans if necessary can help mitigate risks.