According to usatoday.com, Jim Parsons, the actor who played Sheldon, was sick during the worst time. During the fourth season of the series, there's a very important scene between Sheldon and Amy, which was much less pleasant than it looked because Jim was sick with the flu at the time.
Actress Melissa Rauch portrayed Bernadette, who was a very feisty character on the show. But in real life, Melissa is more laid back, and she had to be pushed to be more assertive, according to usatoday.com. She was very convincing on the show, which means she is a great actress.
Kaley and Johnny were a real couple for a little while, but no one else knew about it until later.
According to nickiswift.com, they didn't want the public to know about their romance, but Kaley got tired of keeping it a secret, which is what eventually led to their split.
In 2011, the actors who played Stuart Bloom and Barry Kripke worked on a side project together, according to nickiswift.com. They wrote a script (which had nothing to do with The Big Bang Theory) but it seems that the project wasn't good enough for them to move forward with it.
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